Ubiquitin carboxyl-terminal hydrolase 12

Definition:

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.

References:

[1]. Narmadha Reddy Gangula, et al. WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). J Biol Chem. 2013 Nov 29;288(48):34545-54. [Content Brief]

[2]. Martin A Cohn, et al. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem. 2009 Feb 20;284(8):5343-51. [Content Brief]

[3]. Heng Li, et al. Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20. Mol Cell. 2016 Jul 21;63(2):249-260. [Content Brief]

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