Ubiquitin carboxyl-terminal hydrolase MINDY-1

Definition:

Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

References:

[1]. Yosua Adi Kristariyanto, et al. A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains. EMBO Rep. 2017 Mar;18(3):392-402. [Content Brief]

[2]. Syed Arif Abdul Rehman, et al. MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. Mol Cell. 2016 Jul 7;63(1):146-55. [Content Brief]

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