UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

Definition:

Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.

References:

[1]. Hiroyasu Ishida, et al. A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. FEBS Lett. 2005 Jan 3;579(1):71-8. [Content Brief]

[2]. Akira Seko, et al. Characterization of a novel galactose beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8): the complex formation of beta3Gn-T2 and beta3Gn-T8 enhances enzymatic activity. Glycobiology. 2005 Oct;15(10):943-51. [Content Brief]

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