Uterine leiomyoma

Definition

Uterine leiomyoma, also known as fibroid, is the most common benign neoplasm of the female genital tract. It is a discrete, round, firm, often multiple uterine tumor composed of smooth muscle and connective tissue. The findings derived from high-throughput sequencing combined with previous knowledge have led to an emerging molecular classification of leiomyomas, suggesting that there are several distinct pathogenic pathways involved in leiomyoma formation. The evidence points to at least 4 molecular subclasses: leiomyomas with MED12 mutation, FH inactivation, HMGA2 overexpression, and COL4A6-COL4A5 deletion. While it is thought that the initial events that trigger leiomyoma tumorigenesis involves somatic mutations, it is evident that the development and growth of leiomyoma are highly dependent on ovarian steroid hormones, in particular, progesterone.

References:

[1]. Darlene K Taylor, et al. Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management. F1000Res. 2015 Jul 6;4(F1000 Faculty Rev):183. [Content Brief]

[2]. J Julie Kim, et al. The role of progesterone signaling in the pathogenesis of uterine leiomyoma. Mol Cell Endocrinol. 2012 Jul 25;358(2):223-31. [Content Brief]

[3]. Jennelle C Hodge, et al. Genetic heterogeneity among uterine leiomyomata: insights into malignant progression. Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R7-13. [Content Brief]

[4]. Leo Doherty, et al. Uterine fibroids: clinical manifestations and contemporary management. Reprod Sci. 2014 Sep;21(9):1067-92. [Content Brief]

[5]. Miika Mehine, et al. Genomics of uterine leiomyomas: insights from high-throughput sequencing. Fertil Steril. 2014 Sep;102(3):621-9. [Content Brief]

[6]. Molly B Moravek, et al. Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications. Hum Reprod Update. 2015 Jan-Feb;21(1):1-12. [Content Brief]

生物医学辞典

生物医学辞典は、生物学の学術用語と専門データの包括的で専門的なデータベースです。すべての説明は、権威ある書籍や高いＩＦの文献に基づいており、知りたい生物医学用語の正確な説明を得ることができます。

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