Vacuolar protein sorting-associated protein 53 homolog

Definition:

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.

References:

[1]. Christina Schindler, et al. EARP is a multisubunit tethering complex involved in endocytic recycling. Nat Cell Biol. 2015 May;17(5):639-50. [Content Brief]

[2]. Heike Liewen, et al. Characterization of the human GARP (Golgi associated retrograde protein) complex. Exp Cell Res. 2005 May 15;306(1):24-34. [Content Brief]

[3]. F Javier Pérez-Victoria, et al. Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes. Mol Biol Cell. 2008 Jun;19(6):2350-62. [Content Brief]

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