Ventricular zone-expressed PH domain-containing protein homolog 1

Definition:

Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.

References:

[1]. Premalatha Shathasivam, et al. Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3000-9. [Content Brief]

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