Zinc finger and BTB domain-containing protein 49

Definition:

Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.; [Isoform 1]: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).; [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.

References:

[1]. Bu-Nam Jeon, et al. Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress. Nucleic Acids Res. 2014 Oct;42(18):11447-61. [Content Brief]

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