Zinc finger FYVE domain-containing protein 1

Definition:

Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis. Regulates the morphology, size and distribution of LDs. Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger.

References:

[1]. Guangang Gao, et al. DFCP1 associates with lipid droplets. Cell Biol Int. 2019 Jul 10. [Content Brief]

[2]. Dongfang Li, et al. The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. Cell Rep. 2019 Apr 9;27(2):343-358.e5. [Content Brief]

[3]. S H Ridley, et al. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci. 2001 Nov;114(Pt 22):3991-4000. [Content Brief]

[4]. P C Cheung, et al. Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. Biochem J. 2001 Apr 1;355(Pt 1):113-21. [Content Brief]

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