Zinc finger MIZ domain-containing protein 1

Definition:

Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex.

References:

[1]. Raphael Carapito, et al. ZMIZ1 Variants Cause a Syndromic Neurodevelopmental Disorder. Am J Hum Genet. 2019 Feb 7;104(2):319-330. [Content Brief]

[2]. Xiaomeng Li, et al. The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. J Biol Chem. 2006 Aug 18;281(33):23748-56. [Content Brief]

[3]. Manju Sharma, et al. hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. EMBO J. 2003 Nov 17;22(22):6101-14. [Content Brief]

[4]. Nancy Pinnell, et al. The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia. Immunity. 2015 Nov 17;43(5):870-83. [Content Brief]

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