Zinc finger MYND domain-containing protein 11

Definition:

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.; (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction.

References:

[1]. Guillaume Velasco, et al. New insights into BS69 functions. J Biol Chem. 2006 Jun 16;281(24):16546-50. [Content Brief]

[2]. Matthew R Harter, et al. BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2. PLoS Pathog. 2016 Feb 4;12(2):e1005414. [Content Brief]

[3]. Juncheng Wang, et al. Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding. Cell Res. 2014 Jul;24(7):890-3. [Content Brief]

[4]. H Masselink, et al. The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR. Oncogene. 2000 Mar 16;19(12):1538-46. [Content Brief]

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