Zinc finger SWIM domain-containing protein 7

Definition:

Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Required for meiotic progression, hence for fertility.

References:

[1]. Naif Alhathal, et al. A genomics approach to male infertility. Genet Med. 2020 Dec;22(12):1967-1975. [Content Brief]

[2]. Victoria Martín, et al. Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. EMBO J. 2006 Jun 7;25(11):2564-74. [Content Brief]

[3]. Yang Li, et al. A recurrent ZSWIM7 mutation causes male infertility resulting from decreased meiotic recombination. Hum Reprod. 2021 Apr 20;36(5):1436-1445. [Content Brief]

[4]. Ting Liu, et al. hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem. 2011 Dec 2;286(48):41758-41766. [Content Brief]

[5]. Sinéad M McGlacken-Byrne, et al. ZSWIM7 Is Associated With Human Female Meiosis and Familial Primary Ovarian Insufficiency. J Clin Endocrinol Metab. 2022 Jan 1;107(1):e254-e263. [Content Brief]

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