1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Biperiden Hydrochloride

Biperiden Hydrochloride (Synonyms: KL 373 (Hydrochloride))

Cat. No.: HY-13204 Purity: >98.0%
Handling Instructions

Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.

For research use only. We do not sell to patients.

Biperiden Hydrochloride Chemical Structure

Biperiden Hydrochloride Chemical Structure

CAS No. : 1235-82-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 198 In-stock
Estimated Time of Arrival: December 31
100 mg USD 180 In-stock
Estimated Time of Arrival: December 31
500 mg USD 720 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker. Target: M1 receptors Biperiden is an antiparkinsonian agent of the anticholinergic type. It is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate. It also has a prominent central blocking effect on M1 receptors [2]. Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg),caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty, whereas biperiden and procyclidine did not [3]. Clinical indications: parkinsonism FDA Approved Date: Toxicity: Drowsiness; vertigo; headache; dizziness

Clinical Trial
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (14.37 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8742 mL 14.3711 mL 28.7422 mL
5 mM 0.5748 mL 2.8742 mL 5.7484 mL
10 mM 0.2874 mL 1.4371 mL 2.8742 mL
*Please refer to the solubility information to select the appropriate solvent.
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


BiperidenKL 373KL373KL-373mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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