1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Biperiden

Biperiden  (Synonyms: KL 373)

Cat. No.: HY-13204A Purity: 99.65%
COA Handling Instructions

Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.

For research use only. We do not sell to patients.

Biperiden Chemical Structure

Biperiden Chemical Structure

CAS No. : 514-65-8

Size Price Stock Quantity
5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
10 mg USD 210 In-stock
Estimated Time of Arrival: December 31
25 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Biperiden:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders[1][2].

In Vitro

Biperiden (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Panc-1, Panc-2 and BxPC3 human pancreatic ductal adenocarcinoma cells
Concentration: 29.6 μg/mL
Incubation Time: 72 hours
Result: Inhibited cell proliferation at 72 hours significantly by reducing nuclear c-Rel translocation.
In Vivo

Biperiden (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1].
Biperiden (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; everyday; 3 weeks
Result: Tumor size reduced by 83%.
Animal Model: Male Wistar rats (200-250 g)[2]
Dosage: 8 mg/kg
Administration: Intraperitoneal injection; every 8 hours; 10 days
Result: Reduced late seizures by about three times with no affecting emotional memory damage.
Clinical Trial
Molecular Weight

311.46

Formula

C21H29NO

CAS No.
SMILES

OC([[email protected]]1C[[email protected]@H]2C=C[[email protected]]1C2)(CCN3CCCCC3)C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (160.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2107 mL 16.0534 mL 32.1069 mL
5 mM 0.6421 mL 3.2107 mL 6.4214 mL
10 mM 0.3211 mL 1.6053 mL 3.2107 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Biperiden
Cat. No.:
HY-13204A
Quantity:
MCE Japan Authorized Agent: