2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Biperiden lactate

Biperiden lactate  (Synonyms: KL 373 lactate)

Cat. No.: HY-13204B
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Biperiden (KL 373) lactate is an orally active non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors. Biperiden (KL 373) lactate inhibits acetylcholine and enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders.

For research use only. We do not sell to patients.

Biperiden lactate Chemical Structure

Biperiden lactate Chemical Structure

CAS No. : 7085-45-2

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Biperiden lactate Related Antibodies

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Description

Biperiden (KL 373) lactate is an orally active non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors. Biperiden (KL 373) lactate inhibits acetylcholine and enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders[1][2].

In Vitro

Biperiden lactate (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biperiden lactate Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Panc-1, Panc-2 and BxPC3 human pancreatic ductal adenocarcinoma cells
Concentration: 29.6 μg/mL
Incubation Time: 72 hours
Result: Inhibited cell proliferation at 72 hours significantly by reducing nuclear c-Rel translocation.
In Vivo

Biperiden lactate (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1].
Biperiden lactate (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; everyday; 3 weeks
Result: Tumor size reduced by 83%.
Animal Model: Male Wistar rats (200-250 g)[2]
Dosage: 8 mg/kg
Administration: Intraperitoneal injection; every 8 hours; 10 days
Result: Reduced late seizures by about three times with no affecting emotional memory damage
Clinical Trial
Molecular Weight

401.54

Formula

C24H35NO4
CAS No.
SMILES

OC(C1C2CC(C=C2)C1)(C3=CC=CC=C3)CCN4CCCCC4.OC(C(O)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Biperiden lactate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biperiden7085-45-2KL 373KL373KL-373mAChRMuscarinic acetylcholine receptorMuscarinic receptor antagonistParkinson's diseaseAnticholinergicInhibitorinhibitorinhibit

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