Biperiden lactate
Biperiden (KL 373) lactate is an orally active non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors. Biperiden (KL 373) lactate inhibits acetylcholine and enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders.
For research use only. We do not sell to patients.
- CAS No.: 7085-45-2
- Formula: C24H35NO4
- Molecular Weight:401.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Biperiden lactate (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Panc-1, Panc-2 and BxPC3 human pancreatic ductal adenocarcinoma cells
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Concentration:29.6 μg/mL
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Incubation Time:72 hours
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Result:Inhibited cell proliferation at 72 hours significantly by reducing nuclear c-Rel translocation.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; everyday; 3 weeks
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Result:Tumor size reduced by 83%.
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Animal Model:Male Wistar rats (200-250 g)[2]
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Dosage:8 mg/kg
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Administration:Intraperitoneal injection; every 8 hours; 10 days
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Result:Reduced late seizures by about three times with no affecting emotional memory damage
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 7085-45-2
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Molecular Weight 401.54
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Formula C24H35NO4
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SMILES
OC(C1C2CC(C=C2)C1)(C3=CC=CC=C3)CCN4CCCCC4.OC(C(O)C)=O
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Synonyms
KL 373 lactate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
Purity & Documentation
References
[1]. Leonie Konczalla，et al. Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer. Int J Cancer. 2020 Mar 15;146(6):1618-1630. [Content Brief]
[2]. Simone Bittencourt, et al. Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy. Epilepsy Res. 2017 Dec;138:88-97. doi: 10.1016/j.eplepsyres.2017.10.019. Epub 2017 Oct 29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Biperiden lactate Related Classifications
HY-13204B Related Classifications
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