2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor 5-HT Receptor
  4. cis-(Z)-Flupentixol dihydrochloride

cis-(Z)-Flupentixol dihydrochloride  (Synonyms: cis-(Z)-Flupenthixol dihydrochloride)

Cat. No.: HY-15856
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cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively.

For research use only. We do not sell to patients.

cis-(Z)-Flupentixol dihydrochloride Chemical Structure

cis-(Z)-Flupentixol dihydrochloride Chemical Structure

CAS No. : 51529-01-2

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Other Forms of cis-(Z)-Flupentixol dihydrochloride:

cis-(Z)-Flupentixol dihydrochloride Related Antibodies

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Description

cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively[1][2].

IC50 & Target[2]

D2 Receptor

0.38 nM (Ki)

5-HT2A Receptor

7 nM (Ki)

In Vivo

cis-(Z)-Flupentixol (0.25, or 0.5 mg/kg, i.p.) pretreatment dose-dependently reduces cocaine-induced activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1].
Dosage: 0.125, 0.25, or 0.5 mg/kg.
Administration: IP.
Result: Reduced cocaine-induced activity.
Molecular Weight

507.44

Formula

C23H27Cl2F3N2OS
CAS No.
SMILES

OCCN1CCN(CC/C=C2C3=C(SC4=C\2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (123.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9707 mL 9.8534 mL 19.7068 mL
5 mM 0.3941 mL 1.9707 mL 3.9414 mL
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9707 mL 9.8534 mL 19.7068 mL 49.2669 mL
5 mM 0.3941 mL 1.9707 mL 3.9414 mL 9.8534 mL
10 mM 0.1971 mL 0.9853 mL 1.9707 mL 4.9267 mL
15 mM 0.1314 mL 0.6569 mL 1.3138 mL 3.2845 mL
20 mM 0.0985 mL 0.4927 mL 0.9853 mL 2.4633 mL
25 mM 0.0788 mL 0.3941 mL 0.7883 mL 1.9707 mL
30 mM 0.0657 mL 0.3284 mL 0.6569 mL 1.6422 mL
40 mM 0.0493 mL 0.2463 mL 0.4927 mL 1.2317 mL
50 mM 0.0394 mL 0.1971 mL 0.3941 mL 0.9853 mL
60 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8211 mL
80 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
100 mM 0.0197 mL 0.0985 mL 0.1971 mL 0.4927 mL
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cis-(Z)-Flupentixol dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-(Z)-Flupentixol51529-01-2cis-(Z)-FlupenthixolDopamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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