2. GPCR/G Protein
    Neuronal Signaling
  3. Dopamine Receptor
    5-HT Receptor
  4. cis-(Z)-Flupentixol dihydrochloride

cis-(Z)-Flupentixol dihydrochloride  (Synonyms: cis-(Z)-Flupenthixol dihydrochloride)

Cat. No.: HY-15856
Handling Instructions

cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively.

For research use only. We do not sell to patients.

cis-(Z)-Flupentixol dihydrochloride Chemical Structure

cis-(Z)-Flupentixol dihydrochloride Chemical Structure

CAS No. : 51529-01-2

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Other Forms of cis-(Z)-Flupentixol dihydrochloride:

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Description

cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively[1][2].

IC50 & Target[2]

D2 Receptor

0.38 nM (Ki)

5-HT2A Receptor

7 nM (Ki)

In Vivo

cis-(Z)-Flupentixol (0.25, or 0.5 mg/kg, i.p.) pretreatment dose-dependently reduces cocaine-induced activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1].
Dosage: 0.125, 0.25, or 0.5 mg/kg.
Administration: IP.
Result: Reduced cocaine-induced activity.
Molecular Weight

507.44

Formula

C23H27Cl2F3N2OS
CAS No.
SMILES

OCCN1CCN(CC/C=C2C3=C(SC4=C\2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (123.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9707 mL 9.8534 mL 19.7068 mL
5 mM 0.3941 mL 1.9707 mL 3.9414 mL
10 mM 0.1971 mL 0.9853 mL 1.9707 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

cis-(Z)-Flupentixol51529-01-2cis-(Z)-FlupenthixolDopamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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cis-(Z)-Flupentixol dihydrochloride
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