cis-(Z)-Flupentixol dihydrochloride
Based on 1 publication(s) in Google Scholar
cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively.
For research use only. We do not sell to patients.
- CAS No.: 51529-01-2
- Formula: C23H27Cl2F3N2OS
- Molecular Weight:507.44
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) cis-(Z)-Flupentixol dihydrochloride
MoreAll Dopamine Receptor Isoforms
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
Description
IC50 & Target
[2]|
5-HT2A Receptor |
D2 Receptor 0.38 nM (Ki) |
5-HT2A Receptor 7 nM (Ki) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rats[1].
-
Dosage:0.125, 0.25, or 0.5 mg/kg.
-
Administration:IP.
-
Result:Reduced cocaine-induced activity.
Chemical Information
-
CAS No. 51529-01-2
-
Molecular Weight 507.44
-
Formula C23H27Cl2F3N2OS
-
SMILES
OCCN1CCN(CC/C=C2C3=C(SC4=C\2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl
-
Synonyms
cis-(Z)-Flupenthixol dihydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
bioRxiv
Mesolimbic dopamine signaling mediates increased hedonic feeding and food seeking in lactating mice. [Abstract]2026 Mar 31:2026.03.27.714897. PMID: 41959483
Purity & Documentation
References
[1]. Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6. [Content Brief]
[2]. Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cis-(Z)-Flupentixol dihydrochloride Related Classifications
HY-15856 Related Classifications
Powered by Bioz