IL-2 Protein, Mouse (149a.a)

IL-2 Protein is usually produces by antigen-activated CD4+ T cells, CD8+ T cells, NK cells and NKT cells. IL-2 Protein is involved in signaling pathways including JAK/STAT, inosine phosphate 3-kinase /PI3K, and mitogen-activated protein kinase /MAPK. IL-2 Protein, Mouse (149a.a) is the recombinant mouse-derived IL-2 protein, expressed by E. coli , with tag free. The total length of IL-2 Protein, Mouse (149a.a) is 149 a.a., with molecular weight of ~17.0 kDa.

IL-2 is a receptor cytokine produced by activated CD4-positive helper T cells and plays its role by activating JAK/STAT, inosine phosphate 3-kinase /PI3K and mitogen-activated protein kinase /MAPK. IL-2 binds to receptor complexes consisting of high affinity trimers IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or low affinity dimers IL-2R (IL2RB and IL2RG). IL-2 can increase the cytolytic activity of NK cells. Promote strong proliferation of activated B cells and immunoglobulin production. IL-2 is involved in differentiation and homeostasis of effector T cell subsets, including Th1, Th2, Th17, and memory CD8-positive T cells. IL-2 synthesis is strictly regulated by TCR and CD28 signaling at the mRNA level. It mediates the activation induced cell death (AICD) process. IL-2 can be used in the research of cancer immunotherapy^{[1][2][3][4][5][6]}.

Mouse

E. coli

Tag Free

P04351 (A21-Q169)

16183  [NCBI]

APTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIISTSPQ

Approximately 17.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Abul K Abbas, et al. Revisiting IL-2: Biology and therapeutic prospects. Sci Immunol. 2018 Jul 6;3(25):eaat1482.  [Content Brief]