1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Delcasertib hydrochloride

Delcasertib hydrochloride (Synonyms: KAI-9803 hydrochloride; BMS-875944 hydrochloride)

Cat. No.: HY-106262B
Handling Instructions

Delcasertib hydrochloride (KAI-9803 hydrochloride) is a potent and selective δ-protein kinase C (δPKC) inhibitor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Delcasertib hydrochloride Chemical Structure

Delcasertib hydrochloride Chemical Structure

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5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Delcasertib hydrochloride:

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Description

Delcasertib hydrochloride (KAI-9803 hydrochloride) is a potent and selective δ-protein kinase C (δPKC) inhibitor[1][2].

IC50 & Target[1]

δPKC

 

In Vitro

Delcasertib (KAI-9803) is composed of a selective δ-protein kinase C (δPKC) inhibitor peptide derived from the δV1-1 portion of δPKC (termed “cargo peptide”), conjugated reversibly to the cell-penetrating peptide 11-amino acid, arginine-rich sequence of the HIV type 1 transactivator protein (TAT47–57; termed “carrier peptide”) via a disulfide bond[1].

In Vivo

Delcasertib (KAI-9803, a single intraperitoneal injection) in mice results in the selective inhibition of PKC translocation in the liver, kidney, lung, heart, and brain[1].
Delcasertib (KAI-9803) administration at the end of ischemia has been found to reduce cardiac damage caused by ischemia-reperfusion in a rat model of acute myocardial infarction[1].
Delcasertib (KAI-9803) has been studied for the prevention of reperfusion injury in patients undergoing angioplasty after acute myocardial infarction[2].

Animal Model: Six-week-old male Crl:CD(SD) rats[1]
Dosage: 1 mg/kg (Pharmacokinetic Analysis).
Administration: Via the femoral vein.
Result: The distribution to tissues such as the liver, kidney, and heart is facilitated by the reversible conjugation to TAT47-57.
Molecular Weight

2916.74

Formula

C₁₂₀H₂₀₀ClN₄₅O₃₄S₂

Sequence Shortening

Sequence 1:CYGRKKRRQRRR;Sequence 1':CSFNSYELGSL (Disulfide bridge:Cys1-Cys1’)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DelcasertibKAI-9803BMS-875944KAI9803KAI 9803BMS875944BMS 875944PKCProtein kinase CacutemyocardialinfarctionischemiaInhibitorinhibitorinhibit

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Product Name:
Delcasertib hydrochloride
Cat. No.:
HY-106262B
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