CEL - carboxyl ester lipase Gene

Also Known as BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1056

Summary

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in Cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with Cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

CEL Products (1)

mRNA Protein Name
NM_001807.6 NP_001798.3 bile salt-activated lipase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11834744 GOA
Biological Process GO Annotation Evidence References Source
involved in intestinal cholesterol absorption IDA
IDA: Inferred from direct assay
12031288 GOA
involved in pancreatic juice secretion IDA
IDA: Inferred from direct assay
1854805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bile salt-activated lipase

  • bucelipase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991647 ALX-0651 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-R04602 MicroRNA Mimic Negative Control 97.99% Unkown
HY-RI04602 MicroRNA Inhibitor Negative Control 99.53% Unkown
HY-RI04602A MicroRNA Antagomir Negative Control 99.43% Unkown
HY-R04602A MicroRNA Agomir Negative Control 98.79% Unkown
HY-158099 Biotin-Cel 95.20% Unkown
HY-R04602F FAM-MicroRNA Mimic Negative Control 96.95% Unkown
HY-R04602F1 Cy5-MicroRNA Mimic Negative Control 94.41% Unkown
HY-N0278 Anemonin Inhibitor 99.41% Unkown
HY-171130 Cy3 MicroRNA Antagomir Negative Control 98.85% Unkown
HY-RI04602C FAM-MicroRNA Inhibitor Negative Control 98.26% Unkown
HY-162407 I-As-1 Inhibitor / Unkown
HY-186140 SHP1-IN-2 / Unkown
HY-RS02454 CEL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-R04638 cel-miR-39-3p mimic / Unkown
HY-RS17119 Cel Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23564 Cel Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CEL NCBI
Macaca fascicularis CEL NCBI
Canis lupus familiaris CEL NCBI
Mus musculus CEL NCBI
Susscrofa domestica CEL NCBI
Rattus norvegicus CEL NCBI
Macaca mulatta CEL NCBI