2. Epigenetics TGF-beta/Smad Immunology/Inflammation
  3. PKC NO Synthase
  4. Anemonin

Anemonin  (Synonyms: Pulsatilla camphor; Anemonine; trans-Anemonin)

Cat. No.: HY-N0278 Purity: 99.41%
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Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases.

For research use only. We do not sell to patients.

Anemonin

Anemonin Chemical Structure

CAS No. : 508-44-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Anemonin:

Anemonin Related Antibodies

Top Publications Citing Use of Products

View All PKC Isoform Specific Products:

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases[1][2].

Molecular Weight

192.17

Formula

C10H8O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C=C[C@@]2([C@]3(CC2)C=CC(O3)=O)O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (130.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2037 mL 26.0186 mL 52.0373 mL
5 mM 1.0407 mL 5.2037 mL 10.4075 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2037 mL 26.0186 mL 52.0373 mL 130.0931 mL
5 mM 1.0407 mL 5.2037 mL 10.4075 mL 26.0186 mL
10 mM 0.5204 mL 2.6019 mL 5.2037 mL 13.0093 mL
15 mM 0.3469 mL 1.7346 mL 3.4692 mL 8.6729 mL
20 mM 0.2602 mL 1.3009 mL 2.6019 mL 6.5047 mL
25 mM 0.2081 mL 1.0407 mL 2.0815 mL 5.2037 mL
30 mM 0.1735 mL 0.8673 mL 1.7346 mL 4.3364 mL
40 mM 0.1301 mL 0.6505 mL 1.3009 mL 3.2523 mL
50 mM 0.1041 mL 0.5204 mL 1.0407 mL 2.6019 mL
60 mM 0.0867 mL 0.4336 mL 0.8673 mL 2.1682 mL
80 mM 0.0650 mL 0.3252 mL 0.6505 mL 1.6262 mL
100 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3009 mL
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Anemonin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anemonin508-44-1Pulsatilla camphor Anemonine trans-AnemoninPKCNO SynthaseProtein kinase CNitric oxide synthasesNOSHT-29 celsinflammationulcerative colitisInhibitorinhibitorinhibit

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