2. Disease Areas
  3. Infection
  4. Parasitic Infection
  5. Schistosoma Japonicum Infection

Schistosoma Japonicum Infection

Schistosoma japonicum infection is a parasitic disease caused by trematode worms endemic in parts of Asia, particularly China and the Philippines, with smaller foci in Indonesia. Transmission occurs through contact with freshwater contaminated by cercariae released from infected snails, with bovines serving as major reservoir hosts. Adult worms reside in the mesenteric veins, depositing eggs primarily in the portal system; while some eggs are excreted in feces, many become trapped in tissues, triggering granulomatous inflammation and fibrosis. This leads to intestinal pathology such as ulcerations, pseudopolyps, and tumor-like lesions, along with progressive periportal fibrosis causing pre-sinusoidal portal hypertension. Clinical manifestations range from asymptomatic or mild symptoms (e.g., abdominal pain, bloody diarrhea) to severe complications including growth retardation, splenomegaly, ascites, esophageal varices, and gastrointestinal bleeding. Although liver function is often preserved initially, S. japonicum causes more rapid progression to liver fibrosis and potential liver failure compared to other Schistosoma species. The infection is rare in non-endemic regions, with only a small proportion of imported schistosomiasis cases being attributed to S. japonicum, highlighting challenges in diagnosis outside endemic areas.

Schistosoma Japonicum Infection (5):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-134454
    Z-Pro-Pro-CHO 108708-25-4 98.03%
    Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC50=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC50=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis.
    Z-Pro-Pro-CHO
  • HY-183178
    Teroxalene 14728-33-7
    Teroxalene (Compound VII) is a piperazine-based Schistosomicide. Teroxalene is used for the research of schistosomiasis.
    Teroxalene
  • HY-182621
    MB4253 101264-04-4
    MB4253 is an orally active aliphatic amide and schistosomicidal agent. MB4253 acts against Schistosoma mansoni. MB4253 can be used for the research of schistosomiasis.
    MB4253
  • HY-N19880
    Oleanoglycotoxin A 50657-29-9
    Oleanoglycotoxin A is a saponin present in the berries of Phytolacca dodecandra, with antifertility and molluscicidal activities. Oleanoglycotoxin A prevents pregnancy, reduces the number of embryos, inhibits implantation, terminates established pregnancy, and kills Biomphalaria glabrata. Oleanoglycotoxin A can be used in studies related to schistosomiasis.
    Oleanoglycotoxin A
  • HY-N18199
    rel-Bornyl cinnamate 41755-67-3
    rel-Bornyl cinnamate is an anti-schistosomal agent. rel-Bornyl cinnamate induces round, dark morphological changes, followed by degeneration in Schistosoma mansoni schistosomula. rel-Bornyl cinnamate can be used for the research of schistosomiasis.
    rel-Bornyl cinnamate