Oleanoglycotoxin A 

Oleanoglycotoxin A is a saponin present in the berries of Phytolacca dodecandra, with antifertility and molluscicidal activities. Oleanoglycotoxin A prevents pregnancy, reduces the number of embryos, inhibits implantation, terminates established pregnancy, and kills Biomphalaria glabrata. Oleanoglycotoxin A can be used in studies related to schistosomiasis^[1][2].

Oleanoglycotoxin A is a triglucoside of oleanolic acid with a free carboxylic acid, with the trisaccharide unit attached to the oleanolic acid hydroxyl group, and contains a minor hederagenin-derived component^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oleanoglycotoxin A (100-250 μg; intrauterine; single injection on Day 4 of pregnancy) prevents implantation in pregnant rats at intrauterine doses of 250 μg and 100 μg on Day 4, with complete inhibition of viable embryos at the 100 μg dose^[1].
Oleanoglycotoxin A (100 μg; intrauterine; single injection on Day 6 of pregnancy) terminates established pregnancy in rats at an intrauterine dose of 100 μg on Day 6, resulting in a significant reduction in viable embryos and increase in nonviable/decomposing embryos^[1].
Oleanoglycotoxin A (250-500 μg; intrauterine; single injection on Day 1 of pregnancy) reduces viable embryo counts in pregnant rats at an intrauterine dose of 500 μg on Day 1^[1].
Oleanoglycotoxin A (250 μg; intrauterine; single injection on Day 4 of pregnancy) causes no histological damage to rat uterine endometrium when administered intrauterine at 250 μg on Day 4 of pregnancy^[1].
Oleanoglycotoxin A (3 ppm; aqueous exposure; 24-hour duration) shows potent molluscicidal activity against Biomphalaria glabrata, with an ED₉₀ of 3 ppm at 24 hours^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

943.12

C₄₈H₇₈O₁₈

50657-29-9

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CCC(C)(C4)C)C(O)=O)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)O)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)C)([H])CC2)C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Stolzenberg S J, et al. Blastocidal and contraceptive actions by an extract and compounds from Endod (Phytolacca dodecandra). Contraception, 1976, 14(1): 39-51.

  [2]. Parkhurst R M, et al. Molluscicidal saponins of Phytolacca dodecanra: Oleanoglycotoxin-A. Phytochemistry, 1973, 12: 1437-1442.