SLC5A10 - solute carrier family 5 member 10 Gene

Also Known as SGLT5; SGLT-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 125206

About SLC5A10

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,950,676-19,022,565 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 11 paralogues. Biased expression in kidney (RPKM 27.8), skin (RPKM 6.0) and 1 other tissue.

Summary

This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

SLC5A10 Products (5)

mRNA Protein Name
NM_001042450.4 NP_001035915.1 sodium/glucose cotransporter 5 isoform 2
NM_001270648.3 NP_001257577.1 sodium/glucose cotransporter 5 isoform 3
NM_001270649.2 NP_001257578.1 sodium/glucose cotransporter 5 isoform 4
NM_001282417.1 NP_001269346.1 sodium/glucose cotransporter 5 isoform 5
NM_152351.6 NP_689564.3 sodium/glucose cotransporter 5 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables fructose:sodium symporter activity IDA
IDA: Inferred from direct assay
22212718 GOA
enables mannose:sodium symporter activity IDA
IDA: Inferred from direct assay
22212718 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC5A10 Protein Structure

SSF

SSF: Sodium:solute symporter family (50 - 479)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 596 a.a.
Protein Preferred Names Protein Names

sodium/glucose cotransporter 5

  • Na(+)/glucose cotransporter 5

Related Diseases

Diseases Alias
Histidinemia

  • Histidine Ammonia-Lyase Deficiency

  • Hal Deficiency

  • Histidase Deficiency

  • His Deficiency

  • Histidinuria

  • Hyperhistidinemia

  • HISTID

  • Histidinuria Renal Tubular Defect
Histidine Metabolism Disease

  • Disturbances Of Histidine Metabolism

  • Disorder Of Histidine Metabolism

  • Disturbance Of Histidine Metabolism
Iminoglycinuria

  • Iminoglycinuria, Digenic

  • IG
Benign Familial Infantile Epilepsy

  • Benign Familial Infantile Seizures

  • Bfie

  • Benign Familial Infantile Convulsion

  • Bfic

  • Bfis

  • Benign Familial Infantile Convulsions

  • Familial Benign Neonatal Epilepsy

  • Watanabe-Vigevano Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13283 SLC5A10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC5A10 VGNC VGNC:34903
Canis familiaris SLC5A10 VGNC VGNC:46443
Rattus norvegicus SLC5A10 RGD RGD:1305232
Felis catus SLC5A10 VGNC VGNC:65399
Mus musculus SLC5A10 MGD MGI:1926089
Macaca mulatta SLC5A10 VGNC VGNC:77760
Others SLC5A10 NCBI