FOXF2 - forkhead box F2 Gene

Also Known as FKHL6; FREAC2; FREAC-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2295

About FOXF2

Cytogenetic location: 6p25.3 Genomic coordinates (GRCh38): 6:1,389,576-1,395,603 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 4 paralogues. Biased expression in lung (RPKM 8.4), prostate (RPKM 6.0) and 13 other tissues.

Summary

FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]

FOXF2 Products (1)

mRNA Protein Name
NM_001452.2 NP_001443.1 forkhead box protein F2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
7957066 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8626802 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
8626802 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
9722567 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8626802 GOA
enables TFIIB-class transcription factor binding IPI
IPI: Inferred from physical interaction
9722567 GOA
enables general transcription initiation factor binding IPI
IPI: Inferred from physical interaction
9722567 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7957066 GOA
Biological Process GO Annotation Evidence References Source
involved in genitalia development IMP
IMP: Inferred from mutant phenotype
19276632 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8626802 GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8626802 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8626802 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
29374064 GOA
involved in regulation of protein polyubiquitination IDA
IDA: Inferred from direct assay
29374064 GOA
involved in roof of mouth development IMP
IMP: Inferred from mutant phenotype
19276632 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9722567 GOA
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9722567 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXF2 Protein Structure

Forkhead

Forkhead: Forkhead domain (100 - 192)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
Protein Preferred Names Protein Names

forkhead box protein F2

  • forkhead-like 6

Related Diseases

Diseases Alias
Anterior Segment Dysgenesis 3

  • Iridogoniodysgenesis, Type 1

  • Irid1

  • Iridogoniodysgenesis Anomaly, Autosomal Dominant

  • Igda

  • ASGD3

  • Iris Hypoplasia With Glaucoma

  • Glaucoma Iridogoniodysplasia, Familial

  • Anterior Segment Dysgenesis 3, Multiple Subtypes

  • Iridogoniodysgenesis Type 1

  • Glaucoma Iridogoniodysgenesia

  • Igda Syndrome

  • Iridogoniodysgenesis Anomaly
Acrorenal Syndrome
Blepharophimosis
Axenfeld-Rieger Syndrome

  • Axenfeld Syndrome

  • Rieger Syndrome

  • Rieger Anomaly

  • Axenfeld Anomaly

  • Anomaly, Rieger'S

  • Hagedoom Syndrome

  • Rgs - Rieger Syndrome

  • Rieger'S Anomaly

  • Goniodysgenesis Hypodontia

  • Iridogoniodysgenesis With Somatic Anomalies

  • Ars

  • Axenfeld And Rieger Anomaly

  • Axra

  • Axrs

  • Rieger Eye Malformation Sequence
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Persistent Hyperplastic Primary Vitreous

  • Congenital Retinal Detachment

  • Ncrna Disease

  • Non-Syndromic Congenital Retinal Non-Attachment

  • Pfvs

  • Phpv

  • Persistent Fetal Vasculature Syndrome
Orofacial Cleft

  • Cleft, Orofacial
Anterior Segment Dysgenesis

  • Anterior Segment Developmental Anomaly

  • Anterior Segment Mesenchymal Dysgenesis

  • Corneal Opacification And Other Ocular Anomalies

  • Sclerocornea With Other Ocular Anomalies

  • Asmd

  • Asod

  • Anterior Segment Ocular Dysgenesis

  • Foxe3-Related Ocular Disorder

  • Familial Ocular Anterior Segment Mesenchymal Dysgenesis

  • Dysgenesis, Anterior Segment

  • Irido-Corneal Dysgenesis

  • Axenfeld-Rieger Syndrome, Type 3
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05050 FOXF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FOXF2 VGNC VGNC:29085
Rattus norvegicus FOXF2 RGD RGD:1589717
Mus musculus FOXF2 MGD MGI:1347479
Felis catus FOXF2 VGNC VGNC:62333
Macaca mulatta FOXF2 VGNC VGNC:83424
Canis familiaris FOXF2 VGNC VGNC:40950
Others FOXF2 NCBI