FOXF2 - forkhead box F2 Gene

Homo sapiens

Also known as FKHL6; FREAC2; FREAC-2

Gene ID: 2295 | Gene type: protein coding

About FOXF2

Cytogenetic location: 6p25.3 Genomic coordinates (GRCh38): 6:1,389,576-1,395,603 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 4 paralogues. Biased expression in lung (RPKM 8.4), prostate (RPKM 6.0) and 13 other tissues.

Summary

FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]

FOXF2 Products(1)

mRNA	Protein	Name
NM_001452.2	NP_001443.1	forkhead box protein F2

FOXF2 Protein Structure

Forkhead

0
100
200
300
400
444 a.a.

Protein Preferred Names

Protein Names

forkhead box protein F2

forkhead-like 6

Related Diseases

Diseases

Alias

Anterior Segment Dysgenesis 3

Iridogoniodysgenesis, Type 1	Irid1
Iridogoniodysgenesis Anomaly, Autosomal Dominant	Igda
ASGD3	Iris Hypoplasia With Glaucoma
Glaucoma Iridogoniodysplasia, Familial	Anterior Segment Dysgenesis 3, Multiple Subtypes
Iridogoniodysgenesis Type 1	Glaucoma Iridogoniodysgenesia
Igda Syndrome	Iridogoniodysgenesis Anomaly

Acrorenal Syndrome

Blepharophimosis

Axenfeld-Rieger Syndrome

Axenfeld Syndrome	Rieger Syndrome
Rieger Anomaly	Axenfeld Anomaly
Anomaly, Rieger'S	Hagedoom Syndrome
Rgs - Rieger Syndrome	Rieger'S Anomaly
Goniodysgenesis Hypodontia	Iridogoniodysgenesis With Somatic Anomalies
Ars	Axenfeld And Rieger Anomaly
Axra	Axrs
Rieger Eye Malformation Sequence

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment	Ncrna Disease
Non-Syndromic Congenital Retinal Non-Attachment	Pfvs
Phpv	Persistent Fetal Vasculature Syndrome

Orofacial Cleft

Cleft, Orofacial

Anterior Segment Dysgenesis

Anterior Segment Developmental Anomaly	Anterior Segment Mesenchymal Dysgenesis
Corneal Opacification And Other Ocular Anomalies	Sclerocornea With Other Ocular Anomalies
Asmd	Asod
Anterior Segment Ocular Dysgenesis	Foxe3-Related Ocular Disorder
Familial Ocular Anterior Segment Mesenchymal Dysgenesis	Dysgenesis, Anterior Segment
Irido-Corneal Dysgenesis	Axenfeld-Rieger Syndrome, Type 3

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05050	FOXF2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FOXF2	VGNC	VGNC:29085
Rattus norvegicus	FOXF2	RGD	RGD:1589717
Mus musculus	FOXF2	MGD	MGI:1347479
Felis catus	FOXF2	VGNC	VGNC:62333
Macaca mulatta	FOXF2	VGNC	VGNC:83424
Canis familiaris	FOXF2	VGNC	VGNC:40950

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