ATP10B - ATPase phospholipid transporting 10B (putative) Gene

Also Known as ATPVB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23120

About ATP10B

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:160,563,120-160,929,360 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 13 paralogues. Biased expression in colon (RPKM 23.9), duodenum (RPKM 11.1) and 7 other tissues.

Summary

Enables glycosylceramide flippase activity and phosphatidylcholine flippase activity. Involved in lysosomal membrane organization. Located in endoplasmic reticulum. Is integral component of lysosomal membrane. Part of phospholipid-translocating ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]

ATP10B Products (9)

mRNA Protein Name
NM_001366652.1 NP_001353581.1 phospholipid-transporting ATPase VB isoform 1
NM_001366653.2 NP_001353582.1 phospholipid-transporting ATPase VB isoform 2
NM_001366654.2 NP_001353583.1 phospholipid-transporting ATPase VB isoform 3
NM_001366655.1 NP_001353584.1 phospholipid-transporting ATPase VB isoform 1
NM_001366656.2 NP_001353585.1 phospholipid-transporting ATPase VB isoform 2
NM_001366657.1 NP_001353586.1 phospholipid-transporting ATPase VB isoform 4
NM_001366658.2 NP_001353587.1 phospholipid-transporting ATPase VB isoform 5
NM_001410822.1 NP_001397751.1 phospholipid-transporting ATPase VB isoform 6
NM_025153.3 NP_079429.2 phospholipid-transporting ATPase VB isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycosylceramide flippase activity IDA
IDA: Inferred from direct assay
32172343 GOA
enables phosphatidylcholine flippase activity IDA
IDA: Inferred from direct assay
32172343 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21914794 GOA
Biological Process GO Annotation Evidence References Source
involved in lysosomal membrane organization IDA
IDA: Inferred from direct assay
32172343 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21914794 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
26567335 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
25947375 GOA
located in membrane IDA
IDA: Inferred from direct assay
25947375 GOA
part of phospholipid-translocating ATPase complex IDA
IDA: Inferred from direct assay
25947375 GOA
part of phospholipid-translocating ATPase complex IPI
IPI: Inferred from physical interaction
25947375 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP10B Protein Structure

E1-E2_ATPase

E1-E2_ATPase: E1-E2 ATPase (126 - 391)

HAD

HAD: haloacid dehalogenase-like hydrolase (430 - 1064)

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  • 1200
  • 1461 a.a.
Protein Preferred Names Protein Names

phospholipid-transporting ATPase VB

  • ATPase, class V, type 10B

Related Diseases

Diseases Alias
Waardenburg Syndrome, Type 4c

  • Waardenburg Syndrome Type 4c

  • WS4C

  • Waardenburg Syndrome Type Ivc

  • Waardenburg Syndrome With Hirschsprung Disease Type 4c

  • Waardenburg Syndrome With Hirschsprung Disease, Type 4c

  • Waardenburg Syndrome, Type Ivc

  • Waardenburg Syndrome 4c

  • Hirschsprung Disease With Pigmentary Anomaly

  • Shah-Waardenburg Syndrome

  • Waardenburg-Shah Syndrome

  • Waardenburg Syndrome, Type 4a
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01172 ATP10B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ATP10B MGD MGI:2442688
Rattus norvegicus ATP10B RGD RGD:1565126
Felis catus ATP10B VGNC VGNC:102165
Macaca mulatta ATP10B VGNC VGNC:84281
Others ATP10B NCBI