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NPTXR - neuronal pentraxin receptor Gene

Also Known as NPR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23467

About NPTXR

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,818,452-38,844,028 (from NCBI)

This gene has 1 transcript (splice variant), 195 orthologues and 8 paralogues. Biased expression in brain (RPKM 73.3), heart (RPKM 6.6) and 3 other tissues.

Summary

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]

NPTXR Products (1)

mRNA	Protein	Name
NM_014293.4	NP_055108.2	neuronal pentraxin receptor

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27986928	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27986928	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPTXR Protein Structure

Pentaxin

0
100
200
300
400
500 a.a.

Protein Preferred Names	Protein Names
neuronal pentraxin receptor

Recombinant NPTXR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76522	NPTXR Protein, Human (HEK293, His)	O95502 (A24-A500)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Febrile Seizures, Familial, 6	FEB6 Familial Febrile Seizures 6 Convulsions, Familial Febrile, 6 Familial Febrile Convulsions 6 Febrile Convulsions, Familial, 6
Spinocerebellar Ataxia 23	Spinocerebellar Ataxia Type 23 SCA23 Ataxia, Spinocerebellar, Type 23
Mirror Movements 1	Congenital Mirror Movement Disorder Bimanual Synergia Congenital Mirror Movements Familial Congenital Controlateral Synkinesia Familial Congenital Mirror Movements Hereditary Congenital Controlateral Synkinesia Hereditary Congenital Mirror Movements Isolated Congenital Controlateral Synkinesia Isolated Congenital Mirror Movements Mirror Movements MRMV1 Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum Mirror Movements, Congenital Bimanual Synkinesis Cmm Mirror Movements, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09507	NPTXR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20067	Nptxr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26571	Nptxr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NPTXR	MGD	MGI:1920590
Rattus norvegicus	NPTXR	RGD	RGD:628898
Macaca mulatta	NPTXR	VGNC	VGNC:97108
Bos taurus	NPTXR	VGNC	VGNC:32220
Others	NPTXR	NCBI