GAS1 - growth arrest specific 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2619

About GAS1

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:86,944,362-86,947,506 (from NCBI)

This gene has 1 transcript (splice variant), 216 orthologues and is associated with 6 phenotypes.

Summary

Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]

GAS1 Products (1)

mRNA	Protein	Name
NM_002048.3	NP_002039.2	growth arrest-specific protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21357679	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to vascular endothelial growth factor stimulus	IEP IEP: Inferred from expression pattern	15070677	GOA
involved in negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	8127893	GOA
acts upstream of or within negative regulation of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	11356029	GOA
involved in negative regulation of protein processing	IMP IMP: Inferred from mutant phenotype	21357679	GOA
involved in regulation of ER to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	21357679	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	8127893	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAS1 Protein Structure

GDNF

0
100
200
300
345 a.a.

Protein Preferred Names	Protein Names
growth arrest-specific protein 1	GAS-1

Related Diseases

Diseases	Alias
Septopreoptic Holoprosencephaly	Septopreoptic Hpe
Midline Interhemispheric Variant Of Holoprosencephaly	Mih Mih Type Hpe Mihf Mihv Middle Interhemispheric Fusion Variant Middle Interhemispheric Variant Of Holoprosencephaly Syntelencephaly
Microform Holoprosencephaly	Hpe, Minor Form Hpe-L Holoprosencephaly, Minor Form Holoprosencephaly-Like Microform Hpe
Lobar Holoprosencephaly
Alobar Holoprosencephaly
Semilobar Holoprosencephaly
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Ciliary Dyskinesia, Primary, 33	Primary Ciliary Dyskinesia 33 CILD33 Ciliary Dyskinesia, Primary, 33, Without Situs Inversus Primary Ciliary Dyskinesia 33 Without Situs Inversus
Retinitis Pigmentosa 27	RP27 Retinal Degeneration, Autosomal Recessive, Clumped Pigment Type Retinal Degeneration Autosomal Recessive Clumped Pigment Type RDCP Clumped Pigmentary Retinal Degeneration Retinitis Pigmentosa, Type 27
Glioma
Solitary Median Maxillary Central Incisor	SMMCI Fused Incisors Single Upper Central Incisor Single Central Maxillary Incisor Single Median Maxillary Central Incisor Solitary Median Maxillary Central Incisor Syndrome Incisors Fused Incisors, Fused
Pallister-Hall Syndrome	PHS Hypothalamic Hamartomas Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly Hypothalamic Hamartoblastoma Syndrome Hamartoma Of The Hypothalamus Pallister Hall Syndrome Hall-Pallister Syndrome Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly Hamartoma, Hypothalamic
Brachydactyly, Type A1	Brachydactyly Type A1 BDA1 Farabee-Type Brachydactyly Farabee Type Brachydactyly Brachydactyly Farabee Type Brachydactyly, Farabee Type Brachydactyly A1 Brachydactyly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107199	N-Butylthiophosphoric triamide	Inhibitor	99.76%	Unkown
HY-RS05281	GAS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W016613	Tri(ethylene glycol) monoethyl ether		/	Unkown
HY-RS22178	Gas1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28700	Gas1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GAS1	VGNC	VGNC:29256
Mus musculus	GAS1	MGD	MGI:95655
Canis familiaris	GAS1	VGNC	VGNC:41114
Rattus norvegicus	GAS1	RGD	RGD:1586820
Others	GAS1	NCBI