GAS1 - growth arrest specific 1 Gene

Homo sapiens

Gene ID: 2619 | Gene type: protein coding

About GAS1

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:86,944,362-86,947,506 (from NCBI)

This gene has 1 transcript (splice variant), 216 orthologues and is associated with 6 phenotypes.

Summary

Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]

GAS1 Products(1)

mRNA	Protein	Name
NM_002048.3	NP_002039.2	growth arrest-specific protein 1 precursor

GAS1 Protein Structure

GDNF

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

growth arrest-specific protein 1

GAS-1

Related Diseases

Diseases

Alias

Septopreoptic Holoprosencephaly

Septopreoptic Hpe

Midline Interhemispheric Variant Of Holoprosencephaly

Mih	Mih Type Hpe
Mihf	Mihv
Middle Interhemispheric Fusion Variant	Middle Interhemispheric Variant Of Holoprosencephaly
Syntelencephaly

Microform Holoprosencephaly

Hpe, Minor Form	Hpe-L
Holoprosencephaly, Minor Form	Holoprosencephaly-Like
Microform Hpe

Lobar Holoprosencephaly

Alobar Holoprosencephaly

Semilobar Holoprosencephaly

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome	Gorlin Syndrome
Nbccs	BCNS
Gorlin-Goltz Syndrome	Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
Cerebral Gigantism Jaw Cysts	Cramer Niederdellmann Syndrome
Gorlin Syndrome Or Gorlin-Goltz Syndrome	Naevoid Basal Cell Carcinoma Syndrome

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Ciliary Dyskinesia, Primary, 33

Primary Ciliary Dyskinesia 33	CILD33
Ciliary Dyskinesia, Primary, 33, Without Situs Inversus	Primary Ciliary Dyskinesia 33 Without Situs Inversus

Retinitis Pigmentosa 27

RP27	Retinal Degeneration, Autosomal Recessive, Clumped Pigment Type
Retinal Degeneration Autosomal Recessive Clumped Pigment Type	RDCP
Clumped Pigmentary Retinal Degeneration	Retinitis Pigmentosa, Type 27

Glioma

Solitary Median Maxillary Central Incisor

SMMCI	Fused Incisors
Single Upper Central Incisor	Single Central Maxillary Incisor
Single Median Maxillary Central Incisor	Solitary Median Maxillary Central Incisor Syndrome
Incisors Fused	Incisors, Fused

Pallister-Hall Syndrome

PHS	Hypothalamic Hamartomas
Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly	Hypothalamic Hamartoblastoma Syndrome
Hamartoma Of The Hypothalamus	Pallister Hall Syndrome
Hall-Pallister Syndrome	Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly
Hamartoma, Hypothalamic

Brachydactyly, Type A1

Brachydactyly Type A1	BDA1
Farabee-Type Brachydactyly	Farabee Type Brachydactyly
Brachydactyly Farabee Type	Brachydactyly, Farabee Type
Brachydactyly A1	Brachydactyly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107199	N-Butylthiophosphoric triamide	Inhibitor	99.49%	Unkown
HY-RS05281	GAS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GAS1	VGNC	VGNC:29256
Mus musculus	GAS1	MGD	MGI:95655
Canis familiaris	GAS1	VGNC	VGNC:41114
Rattus norvegicus	GAS1	RGD	RGD:1586820

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