NKX1-1 - NK1 homeobox 1 Gene

Homo sapiens

Also known as SAX2; HSPX153; NKX-1.1

Gene ID: 54729 | Gene type: protein coding

About NKX1-1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,402,932-1,406,442 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 13 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017]

NKX1-1 Products(1)

mRNA	Protein	Name
NM_001290079.1	NP_001277008.1	NK1 transcription factor-related protein 1

NKX1-1 Protein Structure

Homeobox

0
100
200
300
411 a.a.

Protein Preferred Names

Protein Names

NK1 transcription factor-related protein 1

HPX-153 homeobox

Related Diseases

Diseases

Alias

Orofaciodigital Syndrome Viii

Edwards Syndrome	Trisomy 18
Complete Trisomy 18 Syndrome	OFD8
Orofaciodigital Syndrome 8	Trisomy 18 Syndrome
Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis	E3 Trisomy
Oral-Facial-Digital Syndrome Type 8	Orofaciodigital Syndrome Type 8
Ofds Viii	Oral-Facial-Digital Syndrome, Type Viii
Ofd Syndrome 8	Ofds 8
Oral Facial Digital Syndrome 8	Oral Facial Digital Syndrome Type 8
18 Trisomy	Chromosome 18 Trisomy
Trisomy 16-18	Trisomy E
Trisomy E Syndrome	Chromosome 18 Duplication
Oral-Facial-Digital Syndrome, Edwards Type	Orofaciodigital Syndrome, Edwards Type
Chromosome 18, Trisomy	Cleft Lip/Palate With Abnormal Thumbs And Microcephaly
Trisomy 18 Chromosome	Abnormal Autosomes 18

Twin-To-Twin Transfusion Syndrome

Twin To Twin Transfusion Syndrome	Twin Twin Transfusion Syndrome
Fetal Blood Loss From Fetal Hemorrhage Into Co-Twin	Fetal Hemorrhage Into Co-Twin
Twin To Twin Transfusion	Twin-To-Twin Blood Transfer
Fetal Transfusion Syndrome	Fetofetal Transfusion Syndrome
Ttts	Feto-Fetal Transfusion Syndrome
Fetofetal Transfusion	Fetus-To-Fetus Placental Transfusion Syndrome

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09325	NKX1-1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NKX1-1	VGNC	VGNC:107185
Bos taurus	NKX1-1	VGNC	VGNC:106840
Rattus norvegicus	NKX1-1	RGD	RGD:1564874
Canis familiaris	NKX1-1	VGNC	VGNC:43831
Felis catus	NKX1-1	VGNC	VGNC:107355
Mus musculus	NKX1-1	MGD	MGI:109346

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