NKX1-1 - NK1 homeobox 1 Gene
Also Known as SAX2; HSPX153; NKX-1.1
Species: Homo sapiens
About NKX1-1
This gene has 1 transcript (splice variant), 167 orthologues and 13 paralogues. Low expression observed in reference dataset.
Summary
This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017]
NKX1-1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001290079.1 | NP_001277008.1 | NK1 transcription factor-related protein 1 |
NKX1-1 Protein Structure
Homeobox: Homeobox domain (260 - 316)
- 0
- 100
- 200
- 300
- 411 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
NK1 transcription factor-related protein 1 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Orofaciodigital Syndrome Viii |
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| Twin-To-Twin Transfusion Syndrome |
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| Wolf-Hirschhorn Syndrome |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | NKX1-1 | VGNC | VGNC:107185 |
| Bos taurus | NKX1-1 | VGNC | VGNC:106840 |
| Rattus norvegicus | NKX1-1 | RGD | RGD:1564874 |
| Canis familiaris | NKX1-1 | VGNC | VGNC:43831 |
| Felis catus | NKX1-1 | VGNC | VGNC:107355 |
| Mus musculus | NKX1-1 | MGD | MGI:109346 |
| Others | NKX1-1 | NCBI |