GRIP2 - glutamate receptor interacting protein 2 Gene

Homo sapiens

Gene ID: 80852 | Gene type: protein coding

About GRIP2

This gene has 7 transcripts (splice variants), 282 orthologues and 6 paralogues. Broad expression in heart (RPKM 7.1), spleen (RPKM 5.7) and 21 other tissues.

Summary

Predicted to enable protein C-terminus binding activity. Predicted to be involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of AMPA glutamate receptor clustering; and positive regulation of excitatory postsynaptic potential. Predicted to act upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Predicted to be located in cytoplasm; dendritic shaft; and neuron spine. Predicted to be active in glutamatergic synapse and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]

GRIP2 Products(1)

mRNA	Protein	Name
NM_001080423.4	NP_001073892.3	glutamate receptor-interacting protein 2

Protein Preferred Names

Protein Names

glutamate receptor-interacting protein 2

Related Diseases

Diseases

Alias

Fraser Syndrome 1

Fraser Syndrome	Cryptophthalmos With Other Malformations
Cryptophthalmos Syndrome	FRASRS1
Cryptophthalmos-Syndactyly Syndrome	Fraser-Francois Syndrome
Cyclopism	Meyer-Schwickerath'S Syndrome
Ulrich-Feichtiger Syndrome	Cryptophthalmos Syndactyly Syndrome
Fraser'S Syndrome	Meyer-Schwickerath Syndrome
Ullrich-Feichtiger Syndrome

Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6	Parkinson Disease 6
PARK6	Parkinson Disease 6, Early Onset
Parkinson'S Disease 6	Parkinson Disease 6, Early-Onset
Autosomal Recessive Early-Onset Parkinson'S Disease 6	Early-Onset Parkinson Disease 6
Autosomal Recessive Early-Onset Parkinson Disease Type 6	Parkinson Disease 6 Early-Onset
Parkinson Disease 6 Late-Onset Susceptibility To	Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1
Parkinsonism Young Adult Onset	Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1
Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset

Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells	HPS1
Delta Storage Pool Disease	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Hermansky-Pudlak Syndrome, Type 1	Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05810	GRIP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GRIP2	VGNC	VGNC:73221
Bos taurus	GRIP2	VGNC	VGNC:29652
Felis catus	GRIP2	VGNC	VGNC:62715
Canis familiaris	GRIP2	VGNC	VGNC:41499
Rattus norvegicus	GRIP2	RGD	RGD:621668
Mus musculus	GRIP2	MGD	MGI:2681173

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