MLIP - muscular LMNA interacting protein Gene

Homo sapiens

Also known as CIP; MMCKR; C6orf142

Gene ID: 90523 | Gene type: protein coding

About MLIP

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:54,018,970-54,266,280 (from NCBI)

This gene has 13 transcripts (splice variants) and 169 orthologues. Biased expression in heart (RPKM 11.0), liver (RPKM 1.8) and 1 other tissue.

Summary

Predicted to enable lamin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear lumen. Predicted to be active in PML body; nuclear envelope; and sarcolemma. [provided by Alliance of Genome Resources, Apr 2022]

MLIP Products(3)

mRNA	Protein	Name
NM_001281746.2	NP_001268675.1	muscular LMNA-interacting protein isoform 2
NM_001281747.2	NP_001268676.1	muscular LMNA-interacting protein isoform 1
NM_138569.3	NP_612636.2	muscular LMNA-interacting protein isoform 3

MLIP Protein Structure

MLIP

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

muscular LMNA-interacting protein

cardiac ISL1-interacting protein

Related Diseases

Diseases

Alias

Ocular Hypertension

Hypertension, Ocular	Intraocular Pressure Increase
Oh - [Ocular Hypertension]	Oht - [Ocular Hypertension]

Nijmegen Breakage Syndrome

Berlin Breakage Syndrome	NBS
Microcephaly, Normal Intelligence And Immunodeficiency	Ataxia-Telangiectasia Variant
Ataxia-Telangiectasia Variant V1	Seemanova Syndrome Ii
Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome	Seemanova Syndrome Type 2
At-V1	Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies
Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence	Immunodeficiency, Microcephaly, And Chromosomal Instability
Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome	Microcephaly Immunodeficiency Lymphoreticuloma
Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies	Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence
Seemanova Syndrome 2	Ataxia-Telangiectasia Variant 1
Seemanova Syndrome	At V1
Ataxia-Telangiectasia, Variant 1	Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome
V-At	Ataxia Telangiectasia Variant V1

Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant

EDMD2	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy
Emd2	Emery-Dreifuss Muscular Dystrophy, Autosomal Dominant
Scapuloilioperoneal Atrophy With Cardiopathy	Muscular Dystrophy With Early Contractures And Cardiomyopathy, Autosomal Dominant
Hauptmann-Thannhauser Muscular Dystrophy	Cardiomyopathy, Dilated, With Quadriceps Myopathy
Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 2	Muscular Dystrophy, Limb-Girdle, Type 1b
Muscular Dystrophy, Limb-Girdle, Type 1b, Formerly	Lgmd1b, Formerly
Muscular Dystrophy, Proximal, Type 1b, Formerly	Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1b
Lgmd1b	Limb-Girdle Muscular Dystrophy 1b
Muscular Dystrophy, Proximal, Type 1b	Muscular Dystrophy With Early Contractures And Cardiomyopathy Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08491	MLIP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MLIP	MGD	MGI:1916892
Canis familiaris	MLIP	VGNC	VGNC:43259
Rattus norvegicus	MLIP	RGD	RGD:1590513
Macaca mulatta	MLIP	VGNC	VGNC:83434
Bos taurus	MLIP	VGNC	VGNC:31499
Felis catus	MLIP	VGNC	VGNC:63523