ARHGAP11A - Rho GTPase activating protein 11A Gene

Also Known as GAP (1-12)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9824

About ARHGAP11A

Cytogenetic location: 15q13.3 Genomic coordinates (GRCh38): 15:32,615,144-32,639,941 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 260 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 5.9), lymph node (RPKM 5.7) and 19 other tissues.

Summary

This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and Apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast Cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

ARHGAP11A Products (4)

mRNA Protein Name
NM_001286479.3 NP_001273408.1 rho GTPase-activating protein 11A isoform 3
NM_001286480.3 NP_001273409.1 rho GTPase-activating protein 11A isoform 3
NM_014783.6 NP_055598.1 rho GTPase-activating protein 11A isoform 1
NM_199357.3 NP_955389.1 rho GTPase-activating protein 11A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
27957544 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
27957544 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
31883789 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP11A Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (66 - 209)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1023 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 11A

  • rho-type GTPase-activating protein 11A

Related Diseases

Diseases Alias
Benign Pleural Mesothelioma

  • Mesothelioma Of Pleura

  • Benign Neoplasm Of Mesothelial Tissue Of Pleura

  • Pleural Malignant Mesothelioma
Chromosome 15q13.3 Deletion Syndrome

  • Chromosome 15q13.3 Microdeletion Syndrome

  • 15q13.3 Microdeletion Syndrome

  • 15q13.3 Microdeletion

  • Microdeletion 15q13.3 Syndrome

  • Del(15)(Q13.3)

  • Monosomy 15q13.3
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00913 ARHGAP11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARHGAP11A VGNC VGNC:84307
Mus musculus ARHGAP11A MGD MGI:2444300
Rattus norvegicus ARHGAP11A RGD RGD:1309107
Others ARHGAP11A NCBI