Liver Cancer Models

Liver Cancer Models (6):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

Aflatoxin B1	1162-65-8	99.96%
Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation.

N-Nitrosodiethylamine	55-18-5	99.97%
N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Thioacetamide	62-55-5	≥98.0%
Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model.

HY-121107

Chrysene 218-01-9 99.81%

Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties.
HY-131123

N-Nitrosomorpholine 59-89-2 99.91%

N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen.
HY-W025785

Methyl yellow 60-11-7

Methyl yellow (Solvent Yellow 2) is a pH indicator. Methyl yellow appears red at low pH, and becomes yellow above pH 4.0.

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