Lucicebtide 

Lucicebtide (Compound ST101) is a selective antagonist for CCAAT/enhancer binding protein β (C/EBPβ). Lucicebtide binds to the leucine zipper domain of C/EBPβ, prevents its dimerization, and ubiquitin-dependently degrades C/EBPβ. Lucicebtide arrests cell cycle at G0/G1 phase. Lucicebtide exhibits cytotoxicity in cancer cells. Lucicebtide exhibits good pharmacokinetic characters and inhibits tumor growth in mouse model^[1].

4724.46

C₂₀₈H₃₄₅N₆₉O₅₅S

2407100-74-5

d-{Val-Ala-Glu-Ala-Arg-Glu-Glu-Leu-Glu-Arg-Leu-Glu-Ala-Arg-Leu-Gly-Gln-Ala-Arg-Gly-Glu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Leu-Lys-Leu-Gln-Arg}

d-{Val-Ala-Glu-Ala-Arg-Glu-Glu-Leu-Glu-Arg-Leu-Glu-Ala-Arg-Leu-Gly-Gln-Ala-Arg-Gly-Glu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Leu-Lys-Leu-Gln-Arg}

N=C(N)NCCC[C@H](C(O)=O)NC([C@@H](CCC(N)=O)NC([C@@H](CC(C)C)NC([C@@H](CCCCN)NC([C@@H](CC(C)C)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@@H](CC3=CC=CC=C3)NC([C@@H](CCC(N)=O)NC([C@@H](CC(N)=O)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCSC)NC([C@@H](CCCCN)NC([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@@H](CCCCN)NC([C@@H](CCCCN)NC([C@@H](CC(C)C)NC([C@@H](CCC(O)=O)NC(CNC([C@@H](CCCNC(N)=N)NC([C@@H](C)NC([C@@H](CCC(N)=O)NC(CNC([C@@H](CC(C)C)NC([C@@H](CCCNC(N)=N)NC([C@@H](C)NC([C@@H](CCC(O)=O)NC([C@@H](CC(C)C)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCC(O)=O)NC([C@@H](CC(C)C)NC([C@@H](CCC(O)=O)NC([C@@H](CCC(O)=O)NC([C@@H](CCCNC(N)=N)NC([C@@H](C)NC([C@@H](CCC(O)=O)NC([C@@H](C)NC([C@@H](C(C)C)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Darvishi E, et al., Anticancer Activity of ST101, A Novel Antagonist of CCAAT/Enhancer Binding Protein β. Mol Cancer Ther. 2022 Nov 3;21(11):1632-1644.  [Content Brief]