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MB05032 

Cat. No.: HY-16307 Purity: >98.0%
Handling Instructions

MB05032 is a special and efficacious GNG inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.

For research use only. We do not sell to patients.

MB05032 Chemical Structure

MB05032 Chemical Structure

CAS No. : 261365-11-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 264 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 960 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MB05032 is a special and efficacious GNG inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.

IC50 & Target

IC50: 16 nM (Human Liver FBPase)[1]

In Vivo

MB06322 (3/6-300 mg/kg (young/aged Zucker diabetic fatty (ZDF) rats); p.o.; once) results in dose-dependent glucose lowering in young ZDF rats with mild diabetes and aged ZDF rats with overt diabetes[1].

Animal Model: ZDF rats (8- to 9-week-old (mild diabetes) and 12- to 13-week-old (overt diabetes))[1]
Dosage: 3, 6, 10, 30, 300 mg/kg (young ZDF rats); 6, 10, 30, 300 mg/kg (aged ZDF rats)
Administration: Oral administration; once
Result: Results in dose-dependent glucose lowering.
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (165.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3081 mL 16.5404 mL 33.0808 mL
5 mM 0.6616 mL 3.3081 mL 6.6162 mL
10 mM 0.3308 mL 1.6540 mL 3.3081 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

302.29

Formula

C₁₁H₁₅N₂O₄PS

CAS No.

261365-11-1

SMILES

CC(C)CC1=C(C2=CC=C(P(O)(O)=O)O2)N=C(N)S1

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
MB05032
Cat. No.:
HY-16307
Quantity:

MB05032

Cat. No.: HY-16307