2. Academic Validation
  3. Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class

Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class

  • Bioorg Med Chem Lett. 1999 Jan 18;9(2):151-6. doi: 10.1016/s0960-894x(98)00705-7.
N Ouimet 1,  C C Chan,  S Charleson,  D Claveau,  R Gordon,  D Guay,  C S Li,  M Ouellet,  D M Percival,  D Riendeau,  E Wong,  R Zamboni,  P Prasit
Affiliations

Affiliation

  • 1 Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Inc., Pointe Claire-Dorval, Québec, Canada.
PMID: 10021918 DOI: 10.1016/s0960-894x(98)00705-7
Abstract

Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl-2-thiazolylthio)-5-methanesulfonamido-3H-isobe nzofuran-1-one 14 was found to be the optimal compound in the series with superior in vitro and in vivo activities.

Figures