2. Academic Validation
  3. Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria

Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria

  • J Nat Prod. 1999 Feb;62(2):329-31. doi: 10.1021/np980323x.
M Isaka 1,  J Punya,  Y Lertwerawat,  M Tanticharoen,  Y Thebtaranonth
Affiliations

Affiliation

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), Rama 6 Road, Bangkok 10400, Thailand. [email protected]
PMID: 10075777 DOI: 10.1021/np980323x
Abstract

Bioassay-guided fractionation of an extract from the fungus Myrothecium verrucaria BCC 112 resulted in the first isolation of roridin E acetate (5) from nature together with four common macrocyclic trichothecene isomers (1-4). Trichothecenes 1-5, while known as mycotoxins, were evaluated for their high antimalarial activity.

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