2. Academic Validation
  3. On the relationship of OSW-1 to the cephalostatins

On the relationship of OSW-1 to the cephalostatins

  • Bioorg Med Chem Lett. 1999 Feb 8;9(3):419-24. doi: 10.1016/s0960-894x(98)00743-4.
C Guo 1,  T G LaCour,  P L Fuchs
Affiliations

Affiliation

  • 1 Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
PMID: 10091695 DOI: 10.1016/s0960-894x(98)00743-4
Abstract

Antineoplastic bis-steroidal (cephalostatin-type) analogues of the saponin OSW-1 were produced from a dihydroaglycone of OSW-1. The key aglycone 6H was obtained from 5alpha-androstan-3beta-ol-17-one in 8 steps (38% yield). The SAR of the aglycones, intermediates, and hybrid analogues provide insights regarding the proposed common role of C22-oxocarbenium ions in the bioactivity of both OSW-1 and cephalostatins.

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