2. Academic Validation
  3. Cytotoxic polyacetylenes from the marine sponge Petrosia sp

Cytotoxic polyacetylenes from the marine sponge Petrosia sp

  • J Nat Prod. 1999 Apr;62(4):554-9. doi: 10.1021/np9803427.
J S Kim 1,  Y J Lim,  K S Im,  J H Jung,  C J Shim,  C O Lee,  J Hong,  H Lee
Affiliations

Affiliation

  • 1 Research Institute of Drug Development, College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
PMID: 10217707 DOI: 10.1021/np9803427
Abstract

Three C46 (1-3) and three C30 (4-6) polyacetylenic alcohols with cytotoxic activity against a small panel of human solid-tumor cell lines have been isolated from the marine Sponge Petrosia sp. Although compound 1 was identified as the stereoisomer of petrocortyne A, the structures of compounds 2-5 have not been previously reported and were established by spectral methods. Compound 6 was identified as the known compound petrosiacetylene D. The stereochemistry of compounds 1-5 was determined by the modified Mosher's method.

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