2. Academic Validation
  3. UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation

UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation

  • Science. 1999 May 21;284(5418):1372-6. doi: 10.1126/science.284.5418.1372.
O T Keppler 1,  S Hinderlich,  J Langner,  R Schwartz-Albiez,  W Reutter,  M Pawlita
Affiliations

Affiliation

  • 1 Applied Tumor Virology Program, Tumor Immunology Program, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
PMID: 10334995 DOI: 10.1126/science.284.5418.1372
Abstract

Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an Enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.

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