2. Academic Validation
  3. Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin

Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin

  • Bioorg Med Chem Lett. 1999 May 3;9(9):1323-8. doi: 10.1016/s0960-894x(99)00173-0.
J Cottney 1,  Z Rankovic,  J R Morphy
Affiliations

Affiliation

  • 1 Organon Laboratories Ltd., Newhouse, Scotland, UK.
PMID: 10340622 DOI: 10.1016/s0960-894x(99)00173-0
Abstract

Focused libraries of delta opioid ligands were synthesised using REM resin methodology. Several high affinity compounds were identified with good selectivity over the mu Opioid Receptor. Automated REM resin recycling was used to synthesise larger amounts of ligand for in vivo studies.

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