2. Academic Validation
  3. Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis

Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis

  • Bioorg Med Chem Lett. 1999 May 3;9(9):1329-34. doi: 10.1016/s0960-894x(99)00174-2.
D R Barn 1,  A Bom,  J Cottney,  W L Caulfield,  J R Morphy
Affiliations

Affiliation

  • 1 Organon Laboratories Ltd., Newhouse, Scotland, UK.
PMID: 10340623 DOI: 10.1016/s0960-894x(99)00174-2
Abstract

Two focused libraries of delta opioid ligands were synthesised using AlCl3 facilitated aminolysis. Several compounds were identified with DOR binding affinities higher or similar to SNC-80. A novel acyclic derivative of SNC-80 produced antinociception in the acetic acid abdominal constriction test, which is at least partially mediated via the delta-opioid receptor.

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