2. Academic Validation
  3. Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX

Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX

  • FEBS Lett. 1999 Jun 11;452(3):237-42. doi: 10.1016/s0014-5793(99)00640-7.
M Kaneko 1,  T Kudo,  H Iwasaki,  Y Ikehara,  S Nishihara,  S Nakagawa,  K Sasaki,  T Shiina,  H Inoko,  N Saitou,  H Narimatsu
Affiliations

Affiliation

  • 1 Division of Cell Biology, Institute of Life Science, Soka University, Tokyo, Japan.
PMID: 10386598 DOI: 10.1016/s0014-5793(99)00640-7
Abstract

The amino acid sequence of Fuc-TIX is very highly conserved between mouse and human. The number of non-synonymous nucleotide substitutions of the Fuc-TIX gene between human and mouse was strikingly low, and almost equivalent to that of the alpha-actin gene. This indicates that Fuc-TIX is under a strong selective pressure of preservation during evolution. The human Fuc-TIX (hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated by Mn2+ and Co2+, whereas hFuc-TIV and hFuc-TVI were activated by the cations. The hFuc-TIX transcripts were abundantly expressed in brain and stomach, and interestingly were detected in spleen and peripheral blood leukocytes.

Figures