2. Academic Validation
  3. Novel C-ring analogues of 20(S)-camptothecin-part-2: synthesis and in vitro cytotoxicity of 5-C-substituted 20(S)-camptothecin analogues

Novel C-ring analogues of 20(S)-camptothecin-part-2: synthesis and in vitro cytotoxicity of 5-C-substituted 20(S)-camptothecin analogues

  • Bioorg Med Chem Lett. 1999 Jun 21;9(12):1633-8. doi: 10.1016/s0960-894x(99)00268-1.
D Subrahmanyam 1,  A Venkateswarlu,  K Venkateswara Rao,  T V Sastry,  G Vandana,  S A Kumar
Affiliations

Affiliation

  • 1 Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
PMID: 10397491 DOI: 10.1016/s0960-894x(99)00268-1
Abstract

A series of 5-C-substituted 20(S)-camptothecin analogues were synthesised and evaluated their in vitro anti-cancer activity. Several of these analogues have showed excellent activity against human tumor cell lines.

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