Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells

Bioorg Med Chem Lett. 1999 Jul 5;9(13):1843-6. doi: 10.1016/s0960-894x(99)00276-0.

J C Medina ¹, D Roche, B Shan, R M Learned, W P Frankmoelle, D L Clark, T Rosen, J C Jaen

Affiliations

Affiliation

1 Tularik Inc., South San Francisco, CA 94080, USA.

PMID: 10406652 DOI: 10.1016/s0960-894x(99)00276-0

Abstract

In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of beta-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution.

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