2. Academic Validation
  3. 9-Deoxopodophyllotoxin derivatives as anti-cancer agents

9-Deoxopodophyllotoxin derivatives as anti-cancer agents

  • Bioorg Med Chem Lett. 1999 Aug 2;9(15):2131-4. doi: 10.1016/s0960-894x(99)00347-9.
D Subrahmanyam 1,  B Renuka,  G S Kumar,  V Vandana,  D S Deevi
Affiliations

Affiliation

  • 1 Natural Products division, Dr. Reddy's Research Foundation, Hyderabad, India.
PMID: 10465531 DOI: 10.1016/s0960-894x(99)00347-9
Abstract

Several 9-deoxo-9-substituted podophyllotoxin derivatives were synthesised starting from naturally occuring podophyllotoxin and their anti-cancer activity was evaluated against in vitro human Cancer cell line assay. It was observed that these compounds do possess good anti-cancer activity particularly against ovarian, renal and lung Cancer cell lines.

Figures