2. Academic Validation
  3. Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors

Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors

  • Bioorg Med Chem Lett. 1999 Oct 4;9(19):2795-800. doi: 10.1016/s0960-894x(99)00477-1.
K I Choi 1,  J H Cha,  Y S Cho,  A N Pae,  C Jin,  J Yook,  H G Cheon,  D Jeong,  J Y Kong,  H Y Koh
Affiliations

Affiliation

  • 1 Life Sciences Division, Korea Institute of Science and Technology, Seoul.
PMID: 10522693 DOI: 10.1016/s0960-894x(99)00477-1
Abstract

A series of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles synthesized showed different binding characteristics to acetylcholine receptors depending on the substituents on the phenyl ring. Small polar substituents gave preferential binding affinity to nicotinic receptors, and large hydrophobic substituents to muscarinic receptors.

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