2. Academic Validation
  3. Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase

Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase

  • Biochim Biophys Acta. 1999 Sep 3;1446(3):383-8. doi: 10.1016/s0167-4781(99)00105-0.
G Rumsby 1,  D P Cregeen
Affiliations

Affiliation

  • 1 Department of Molecular Pathology, University College London, Windeyer Institute of Medical Sciences, UK. [email protected]
PMID: 10524214 DOI: 10.1016/s0167-4781(99)00105-0
Abstract

The isolation and expression of a human liver cDNA encoding a 40-kDa protein with glyoxylate and hydroxypyruvate reductase activities is described. The cDNA (GLXR) is 1235 bp and consists of a predicted open reading frame of 987 bp with a 225-bp 3'-untranslated region. The 328-amino acid protein has partial sequence similarity to hydroxypyruvate and glyoxylate reductases from a variety of plant and microbial species.

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