2. Academic Validation
  3. Stabilization of microtubules by Combretastatin D derivatives

Stabilization of microtubules by Combretastatin D derivatives

  • Bioorg Med Chem Lett. 1999 Oct 18;9(20):2927-8. doi: 10.1016/s0960-894x(99)00503-x.
E A Couladouros 1,  T Li,  V I Moutsos,  E N Pitsinos,  I C Soufli
Affiliations

Affiliation

PMID: 10571149 DOI: 10.1016/s0960-894x(99)00503-x
Abstract

The effect of five derivatives of Combretastatin D on tubulin polymerization was investigated. All of them were found to stabilize microtubules to various degrees. The derivatives bearing polar substituents were found to be the most active.

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