2. Academic Validation
  3. Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity

Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity

  • Bioorg Med Chem Lett. 2000 Mar 6;10(5):495-8. doi: 10.1016/s0960-894x(00)00042-1.
D L Boger 1,  M Searcey,  W C Tse,  Q Jin
Affiliations

Affiliation

  • 1 Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. [email protected]
PMID: 10743956 DOI: 10.1016/s0960-894x(00)00042-1
Abstract

The series of four dimers derived from head to tail coupling of the two enantiomers of the duocarmycin SA alkylation subunit are described.

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