2. Academic Validation
  3. Flavonol-cinnamate cycloadducts and diamide derivatives from Aglaia laxiflora

Flavonol-cinnamate cycloadducts and diamide derivatives from Aglaia laxiflora

  • J Nat Prod. 2000 Apr;63(4):473-6. doi: 10.1021/np990454d.
Y J Xu 1,  X H Wu,  B K Tan,  Y H Lai,  J J Vittal,  Z Imiyabir,  L Madani,  K S Khozirah,  S H Goh
Affiliations

Affiliation

  • 1 Department of Chemistry, National University of Singapore.
PMID: 10785416 DOI: 10.1021/np990454d
Abstract

Leaf extracts of the Malaysian plant Aglaia laxiflora provided two cytotoxic compounds, a new rocaglaol rhamnoside (1), a known rocaglaol (2), new (but inactive) flavonol-cinnamaminopyrrolidine adducts (3-6), and their probable biosynthetic precursors (7 and trimethoxyflavonol). All structures were elucidated primarily by 2D NMR spectroscopy. The structure and stereochemistry of aglaxiflorin A (3) were confirmed by single-crystal X-ray crystallography.

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