2. Academic Validation
  3. Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues

Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues

  • Bioorg Med Chem Lett. 2000 May 15;10(10):1003-5. doi: 10.1016/s0960-894x(00)00126-8.
Z Y Yang 1,  Y Xia,  P Xia,  A Brossi,  L M Cosentino,  K H Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
PMID: 10843202 DOI: 10.1016/s0960-894x(00)00126-8
Abstract

DCK lactam analogues were synthesized and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 4-Methyl-DCK lactam (11a) exhibited potent anti-HIV activity with EC50 and therapeutic index values of 0.00024 microM and 119,333, respectively.

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